Fillerina 12 HA Densifying-Filler is the first dermocosmetic filling treatment for external application that can be used at home. It should be used every day for 14 days, in the morning or at night, depending on individual needs and habits. The application is performed by means of a special Applicator, which allows for the withdrawal of a specific amount of product and its precise release in the targeted areas, such as age wrinkles and expression lines or on the cheeks and lips for increased volume.
Dosages: Grade 3, Grade 4, Grade 5.
Fillerina 12HA Densifying-Filler presents a blend of 12 different Hyaluronic Acid molecules with varied molecular weights and sizes that are especially effective in penetrating the skin layers (ex vivo tests with Franz Cells), allowing the tissues to be filled and revitalized. The molecular weights of the 12 Hyaluronic Acids with filling effect in this formulation range from 400 to 2000000 Dalton, including one Crosspolymer molecule, and all have shown great penetration capacity (ex vivo test).
The Fillerina 12HA Densifying-Filler also combines 3 Collagen molecules with different molecular weights (2,000, 12,000, and 300,000 Da) that, when penetrating up to the dermis (ex vivo tests with Franz Cells), can promote an increase in extracellular matrix density and improve the filling effect, synergistically with the Hyaluronic Acid molecules. With chronological aging, the quantity and quality of Elastin, the protein that constitutes elastic fibers, drastically decreases, thus threatening the skin's plasticity and contributing to skin sagging. The formulation combines 2 Elastin molecules with different molecular weights (1,400 Da and 2,200 Da) aimed at compensating for this loss and restoring skin elasticity and plasticity.
Over 14 days, the 12 Hyaluronic Acids contained in Fillerina perform their fundamental action in skin filling and volumizing, producing a FILLING effect on skin depressions (wrinkles, furrows, and sagging facial features), and in areas to be intensified, such as cheeks and lips.
Ex vivo and in vivo efficacy tests demonstrate the excellent results that can be achieved with the application of Hyaluronic Acid molecules capable of penetrating the skin by crossing the cutaneous layers due to their diversified molecular weights.
In particular, the in vivo study on Fillerina, conducted on 40 women in double-blind, placebo-controlled conditions, was subject to a scientific publication in the prestigious JOURNAL OF COSMETIC DERMATOLOGY, published by Wiley, one of the most important international scientific publishers. This journal is the official agency of the International Academy of Cosmetic Dermatology, based in Philadelphia, USA.
CLINICAL-INSTRUMENTAL STUDY RESULTS
**Wrinkle Depth Reduction**
Treatment with Fillerina active products determined a reduction of -8.4%, -14.5%, and -21.8% in wrinkle depth, respectively after 7, 14, and 30 days of treatment. 95% of subjects showed positive results at 14 and 30 days.
*Average Result:* -21.8%; *Maximum Result:* -54.8%.
**Wrinkle Volume Reduction**
Treatment with Fillerina active products resulted in an average reduction in wrinkle volume of -11.3%, -18.4%, and -26.3%, respectively after 7, 14, and 30 days of treatment. 95% of subjects showed positive results at 14 and 30 days.
*Average Result:* -26.3%; *Maximum Result:* -48.1%.
**Increase in Cheek Volume**
The data measure the variation in distance between the contours of the cheeks and a line passing through the nose, expressed in millimeters.
*Average Result:* +2.27 mm; *Maximum Result:* +3.39 mm.
**Elevation of Cheeks**
Cheek Elevation measures the reduction in distance between the contours of the cheeks and a horizontal line intersecting the eyes, expressed in millimeters.
*Average Result:* -2.51 mm; *Maximum Result:* -3.67 mm.
**Facial Features Elevation**
The data measure the distance between the top (forehead) and bottom (jaw) of the face at 5 points and are expressed in millimeters. Negative number = reduction in distance = reshaping action on the face oval.
*Average Result:* -1.32 mm; *Maximum Result:* -2.87 mm.
**Lip Volume Increase**
The lip volume increase effect was calculated based on mathematical interpolation of the following parameters: 1) length of the lip margin, 2) height of the upper lip, and 3) height of the lower lip.
*Average Result:* +14.2%; *Maximum Result:* +44.7%.
1. Drink two glasses of water before applying Fillerina Filling Gel to facilitate its action and effectiveness.
2. Clean the skin and free it from sebum and impurities.
3. Take 2 ml of Filling Gel with the special Applicator and apply it precisely to the desired areas.
4. Let the gel work for about 10 minutes. Do not massage or make circular movements. With fingertips or palms, tap gently on the remaining product to complete the application.
5. Take 1 - 2 ml of Nourishing Cream and apply it to the entire face and neck.
6. Tap gently to facilitate absorption.
Fillerina 12 HA Densifying-Filler - Gel
Water, Glycerin, Hydrolyzed Glycosaminoglycans, Sodium Hyaluronate, Caprylyl Glycol, Carbomer, 1,2-Hexanediol, Pentylene Glycol, Hydrolyzed Elastin, Butylene Glycol, Sodium Hyaluronate Crosspolymer, Hydrolyzed Hyaluronic Acid, Hydrolyzed Collagen, Hyaluronic Acid, Tropolone, Hydroxypropyl Cyclodextrin, Phenoxyethanol, Hydrolyzed Sodium Hyaluronate, Decylene Glycol, Xanthan Gum, Leuconostoc/Radish Root Ferment Filtrate, Sodium Chondroitin Sulfate, Soluble Collagen, Palmitoyl Tripeptide-38, Phenylpropanol, Palmitoyl Hexapeptide-52, Acetyl Hexapeptide-37, Palmitoyl Heptapeptide-18, Sodium Benzoate, Glycolic Acid, Sodium Hydroxide, Ethylhexylglycerin, Glyceryl Caprylate, Disodium EDTA, Sodium Chloride, Sorbic Acid, Lactic Acid, Polyvinyl Alcohol.
Fillerina 12 HA Densifying-Filler - Nourishing Film
Water, Cyclopentasiloxane, Glycerin, HDI/Trimethylol Hexyllactone Crosspolymer, Polysilicone-11, C30-45 Alkyl Cetearyl Dimethicone Crosspolymer, Dimethicone, Steareth-2, Xylitol, Butylene Glycol, Steareth-21, Limnanthes Alba Seed Oil, Phenoxyethanol, Boron Nitride, Hydrogenated Lecithin, Ammonium Acryloyldimethyltaurate/VP Copolymer, Tocopheryl Acetate, Stearic Acid, Palmitic Acid, Benzophenone-4, Parfum, Benzophenone-3, Allantoin, Xanthan Gum, Lecithin, Butyrospermum Parkii Butter, Silica, Pseudoalteromonas Ferment Extract, Limonene, Linalool, Hexyl Cinnamal, Acetyl Hexapeptide-30, Geraniol, Citronellol, Coumarin, Citral, Caprylyl Glycol, Arginine, Diazolidinyl Urea, Salicylic Acid, Sodium Hydroxide, Sodium Chloride, Alcohol, BHT, Disodium EDTA.